The major histocompatibility complex determines susceptibility to cytotoxic T cells directed against minor histocompatibility antigens.

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The major histocompatibility complex determines susceptibility to cytotoxic T cells directed against minor histocompatibility antigens

Cytotoxic cells were generated by immunizing one strain of mouse with cells from an allogeneic strain which carries the same H-2 region. The effector cells assayed in a 4 h 51Cr release assay were shown to be T cells and indistinguishable, except in specificity, from cytotoxic T cells directed at H-2 alloantigens. Although the genetic differences between responder and stimulator cells responsib...

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Human minor histocompatibility antigens.

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Frequency of Major Histocompatibility Antigens Class I in Mazandaran Province

 Background and purpose: Major histocompatibility antigens are the most polymorphic components of the immune system. The purpose of this study was to determine the frequency of human leukocyte antigens (HLA) in a population in Mazandaran province, Iran. Materials and methods: In a cross sectional study, peripheral blood samples were obtained from 550 people in Immunogenetics Research Center af...

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Recognition of minor histocompatibility antigens on lymphocytic and myeloid leukemic cells by cytotoxic T-cell clones.

Clinical studies indicated an enhanced antileukemic effect of allogeneic bone marrow transplantation (BMT), as compared with autologous BMT. After allogeneic HLA-identical BMT, donor-derived cytotoxic T lymphocytes (CTLs) directed at minor histocompatibility (mH) antigens on the recipients, tissues can be shown. To evaluate the antileukemic reactivity of mH antigen-specific CTLs, we analyzed th...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1975

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.142.6.1349